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Karyotyping, often referred to as the "KUNDALI" of the 21st century, plays a crucial role in understanding an individual's genetic makeup. Just as different planets have varying effects on individuals as different genes influence our physical and mental development. However, faulty genes can act as carriers of various diseases. Genetic studies can predict the likelihood of birth defects or increased risks of certain conditions. Such tests as FISH, PCR, NGS, Microarray, and Flow cytometry have become vital tools in molecular and cytogenetic testing for disease identification.