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 Prenatal invasive testing, by amniocentesis, chorionic villus sampling (CVS), and fetal blood, is essential for identifying genetically abnormal pregnancies. 

These procedures allow for the study of prenatal chromosomes and enable the detection of conditions like Trisomy 13, 18, 21, X & Y syndromes, as well as microdeletion syndromes.

 Invasive FISH investigations aid in diagnosing specific genetic disorders. 

Prenatal invasive testing is recommended for high-risk patients, those with abnormal ultrasound findings, a family history of chromosomal abnormalities, carriers of abnormal chromosomes, and those with a previous child with a chromosomal abnormality.