BCR-ABL Quantification (Major and Minor) by RT PCR in Ahmedabad

Sterling Accuris Diagnostics introduces the BCR-ABL Quantification (Major and Minor) by RT PCR test in Ahmedabad, a critical diagnostic tool for certain types of leukaemia.

Overview of the BCR-ABL Quantification (Major and Minor) by RT PCR

This test uses RT PCR (Reverse Transcription Polymerase Chain Reaction) technology to measure the amount of BCR-ABL gene fusion in the blood or bone marrow.

RTPCR is a laboratory technique to detect and measure specific genetic material in a sample. It starts by converting RNA (a molecule related to DNA) into DNA and then rapidly makes multiple copies of that DNA. This amplification makes detecting even tiny amounts of genetic material more manageable, which helps diagnose diseases, monitor treatment responses, and conduct scientific research for different leukaemias using the BCR-ABL Quantification (Major and Minor) by RT PCR test in Ahmedabad.

The BCR-ABL gene fusion is a specific genetic abnormality often found in chronic myeloid leukaemia (CML) and sometimes in acute lymphoblastic leukaemia (ALL). The changed chromosome 22 is called a "Philadelphia chromosome (Ph)" after the city where researchers discovered it.

Why is the test for BCR-ABL Quantification by RT PCR in Ahmedabad Done?

The test is essential for:

• Diagnosing CML and Ph+ve ALL when BCR-ABL gene fusion is suspected.
• Monitoring the response to treatment in patients.
• Determining the disease's progression over time.

BCR-ABL Quantification by RT PCR: Main Highlights

• Instructions: No special fasting is required. A doctor's prescription is mandatory.
• Recommended Age: Suitable for all ages, particularly in suspected cases of CML or Ph+ve ALL.
• Sample Type for Test: Typically, a blood sample or bone marrow aspirate.
• TAT: Results are generally available within a few days to a week.

FAQs

What is the significance of BCR-ABL quantification?

The BCR-ABL gene fusion level helps understand the disease's severity and guide treatment.

What makes RT PCR a preferred method?

RT PCR is highly sensitive and can detect even low levels of the BCR-ABL fusion gene.

What does it mean if my test shows abnormal white blood cells, the BCR-ABL1 gene, and the Philadelphia chromosome?

These findings typically indicate a diagnosis of chronic myeloid leukaemia (CML) or Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ ALL). Both are types of blood cancer associated with these specific genetic markers.

Can someone have CML without the Philadelphia chromosome?

While it's possible to have CML without the Philadelphia chromosome,  The presence of the Philadelphia chromosome is a key indicator of CML.

How are BCR-ABL1 test results used to monitor cancer treatment?

Your healthcare provider will compare the current amount of BCR-ABL1 in your sample with previous results to assess how your cancer responds to treatment. A decrease or increase in BCR-ABL1 levels provides crucial information about the effectiveness of the therapy.

What does a decrease in BCR-ABL1 levels mean?

A decrease in BCR-ABL1 levels suggests that your treatment is effective.

What does an increase in BCR-ABL1 levels indicate?

Increased BCR-ABL1 levels might mean the treatment isn't working as expected. Your healthcare provider may consider alternative therapies or additional testing in such cases.

Are there any risks with this test?

The test involves a standard blood draw or bone marrow collection with minimal associated risk.

Why Choose Sterling Accuris Diagnostics in Ahmedabad for this Test?

Sterling Accuris Diagnostics is renowned for its precision and reliability. Our state-of-the-art RT PCR technology ensures accurate quantification of BCR-ABL gene fusion. We offer a convenient home collection service in Ahmedabad, ensuring a seamless experience for our patients. Secure your health with informed decisions. Today, book the BCR-ABL Quantification (Major and Minor) by RT PCR test in Ahmedabad with Sterling Accuris Diagnostics.