MGMT-MS-PCR in Palanpur
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Pre Instructions
Recommended by Health Experts
NABL Accredited Labs
Age Group 05-90 years
Recommended for Men, Women
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MGMT Hypermethylation1
FAQ
What is the role of the MGMT gene in chemotherapy with alkylating agents?
MGMT enzyme is involved in DNA repair that removes alkylating agents and therefore makes chemotherapy ineffective. Methylation of the MGMT gene enhances sensitivity to chemotherapy drugs, and DNA methylation can impede transcription.
Why should you book an MGMT-MS-PCR test with Sterling Accuris?
Sterling Accuris specializes in providing quick and reliable diagnosis support for physicians and healthcare facilities across the country. We offer an MGMT-MS-PCR test in Palanpur with timely reports.
What are the advantages of detected hypermethylation using Methylation specific-PCR or MS-PCR?
Methylation-specific PCR is a valuable method for qualitative analysis of DNA methylation with several benefits, such as straightforward design and application, the ability to detect small amounts of methylated DNA, and efficient screening of numerous samples.
What are gliomas?
Gliomas refer to diverse primary brain tumors that arise from glial cells, possessing molecular heterogeneity. The two most frequent subtypes are astrocytomas and oligodendrogliomas, further differentiated as low- and high-grade gliomas. Depending on the histology and grade, clinical presentations, treatments, and outcomes will differ accordingly.
What other packages does Sterling Accuris offer?
Sterling Accuris offers a range of packages including Senior citizen (male and female) package, healthy heart profile, diabetes profile, vitamin profile, covid immunity package and much more. Visit our website to learn more about these packages.
What makes Sterling Accuris a better pathology lab than others?
For us, precision care, safe sample collection, timely delivery of reports, and precise reporting of patient results while adhering to health and safety precautions are the cornerstone of our success.
Do you provide home visit/collection service?
Yes. We do provide home collection services at your doorstep.
Please go ahead and book your visit today from our top menu options in this website / chat or do call us on 812 813 0000.
How long does it take to receive test results?
Though most tests are completed and reported within about 24 hours of receiving the sample for testing, certain tests take several days to weeks.
Your soft copy will be sent on registered email id and Whatsapp. Also, you will receive SMS with link to download your report. Also, your report is available on our website / app.
To know the status of the report, you can call our customer care team on 812 813 0000.
Is there any preparation or precautions for patient before tests or body checkup?
Fasting maybe required in case of a few tests to ensure accurate results.
In general, it is also advisable to abstain from alcohol and heavy diet at least for 24 hours before any health test. You can see the requirement for each test on the product page on our website / app.
MGMT-MS-PCR test in Palanpur
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Sterling Accuris offers the MGMT-MS-PCR Test in Palanpur to check for abnormal methylation of genes, which is important for predicting response of cancer to alkylating therapy.
Overview of the MGMT-MS-PCR Test
Methylation of cytosines located 5′ to guanosine has a major effect on the expression of a number of eukaryotic genes. But aberrant methylation of genes which are usually unmethylated has been shown to be involved in the transformation of a cell and tumour formation. One such transformation occurs by hypermethylation of O (6)-Methylguanine DNA methyltransferase (MGMT). MGMT hypermethylation has been found to be associated with glioblastoma, adenocarcinoma, lymphoma, colon and many other types of cancers. Methylation-specific PCR (MS-PCR) is a new technique in which abnormal gene methylation is detected using a small amount of DNA.
The MGMT-MS-PCR test can provide important clues about abnormal hypermethylation of the MGMT gene and is helpful for clinicians in planning treatment. Book an MGMT-MS-PCR test near you to detect hypermethylation of the MGMT gene which is important for predicting response to therapy.
Why and When is an MGMT-MS-PCR Test Done?
Glioblastoma is a fast-growing aggressive brain tumor. The methylation of the MGMT gene is a reliable biomarker for predicting responsiveness to treatment with alkylating drugs and the prognosis of the disease in glioblastoma multiforme, the most common primary brain tumor. If a person is suffering from glioblastoma, then this test may be recommended to assess the success of the chemotherapy with alkylating agents. A person with the following symptoms of glioblastoma may need this test:
- Persistent headache
- Blurred or double vision
- Vomiting
- The onset of speech difficulties gradually
- Onset of seizures
- Change in ability to think and learn
- Changes in mood and personality
- Loss of appetite
Sterling Accuris Palanpur offers a reliable MGMT-MS-PCR test in Palanpur with timely reports.
MGMT-MS-PCR Test: Main Highlights
- Instructions: Fasting is not required
- Recommended Age: All age groups
- Sample type for test: Glioblastoma tissue or tumor tissue
How to Interpret the MGMT-MS-PCR Test Report
Interpretation of the results for the MGMT-MS-PCR test in adult females and males is given in the table:
| Parameter | Result |
| MGMT hypermethylation | Detected: Positive Not detected: Negative |
Causative factors that increase risk of getting the disorder:
- Obesity
- Smoking
- Prolonged use of drugs like morphine
- Chemical exposure
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